Inhibitory effects of bakuchiol, bavachin, and isobavachalcone isolated from piper longum on melanin production in b16 mouse melanoma cells

Osamu Ohno, Taeko Watabe, Kazuhiko Nakamura, Masaru Kawagoshi, Nobuo Uotsu, Tomohiro Chiba, Masayoshi Yamada, Kohji Yamaguchi, Kaoru Yamada, Kenji Miyamoto, Daisuke Uemura

研究成果: Article査読

33 被引用数 (Scopus)

抄録

An EtOH extract of fruits of Piper longum was found to exhibit a potent inhibitory effect against a-melano-cyte-stimulating hormone (α-MSH)- induced melanin production in B16 mouse melanoma cells. Bioassay-directed fractionation led to the isolation of prenylated phenolic compounds bakuchiol, bavachin, and isobava-chalcone. These compounds and the crude extract of the fruits of P. longum may have suppressive effects against pigmentation by melanin in the skin.

本文言語English
ページ(範囲)1504-1506
ページ数3
ジャーナルBioscience, Biotechnology and Biochemistry
74
7
DOI
出版ステータスPublished - 2010

ASJC Scopus subject areas

  • バイオテクノロジー
  • 分析化学
  • 生化学
  • 応用微生物学とバイオテクノロジー
  • 分子生物学
  • 有機化学

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