TY - JOUR
T1 - Initial predictors of development of pure red cell aplasia in myasthenia gravis after thymectomy
AU - Suzuki, Shigeaki
AU - Nogawa, Shigeru
AU - Tanaka, Kortaro
AU - Koto, Atsuo
AU - Fukuuchi, Yasuo
AU - Kuwana, Masataka
N1 - Funding Information:
The authors thank Kyoko Kimura for her expert technical assistance and Drs. Masafumi Kawamura and Makoto Sawafuzi for their helpful suggestions. This work was supported by a grant from Japanese Ministry of Education, Science, Sports and Culture.
PY - 2003/12
Y1 - 2003/12
N2 - Pure red cell aplasia (PRCA) is well known to be concomitant with myasthenia gravis (MG), but it is difficult to predict the development of PRCA in patients with MG. Of 135 patients with MG, four (2.9%) had PRCA. All patients developed PRCA after thymectomy during a period when MG was in remission. The frequencies of thymoma, bulbar involvement and high anti-acetylcholine receptor (AChR) antibody levels were significantly higher in four patients with PRCA. Japanese MG patients with these characteristics at presentation were at significant risk for the development of PRCA after thymectomy.
AB - Pure red cell aplasia (PRCA) is well known to be concomitant with myasthenia gravis (MG), but it is difficult to predict the development of PRCA in patients with MG. Of 135 patients with MG, four (2.9%) had PRCA. All patients developed PRCA after thymectomy during a period when MG was in remission. The frequencies of thymoma, bulbar involvement and high anti-acetylcholine receptor (AChR) antibody levels were significantly higher in four patients with PRCA. Japanese MG patients with these characteristics at presentation were at significant risk for the development of PRCA after thymectomy.
KW - HLA class II
KW - Myasthenia gravis
KW - Pure red cell aplasia
KW - Thymectomy
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U2 - 10.1016/S0303-8467(03)00061-1
DO - 10.1016/S0303-8467(03)00061-1
M3 - Article
C2 - 14643910
AN - SCOPUS:0344982901
SN - 0303-8467
VL - 106
SP - 16
EP - 18
JO - Clinical Neurology and Neurosurgery
JF - Clinical Neurology and Neurosurgery
IS - 1
ER -