Innate lymphoid cells in organ fibrosis

Yohei Mikami, Yoshiaki Takada, Yuya Hagihara, Takanori Kanai

研究成果: Short survey査読

18 被引用数 (Scopus)


Innate lymphoid cells (ILCs) are a recently identified family of lymphoid effector cells. ILCs are mainly clustered into 3 groups based on their unique cytokine profiles and transcription factors typically attributed to the subsets of T helper cells. ILCs have a critical role in the mucosal immune response through promptly responding to pathogens and producing large amount of effector cytokines of type 1, 2, or 3 responses. In addition to the role of early immune responses against infections, ILCs, particularly group 2 ILCs (ILC2), have recently gained attention for modulating remodeling and fibrosis especially in the mucosal tissues. Herein, we overview the current knowledge in this area, highlighting roles of ILCs on fibrosis in the mucosal tissues, especially focusing on the gut and lung. We also discuss some new directions for future research by extrapolating from knowledge derived from studies on Th cells.

ジャーナルCytokine and Growth Factor Reviews
出版ステータスPublished - 2018 8月

ASJC Scopus subject areas

  • 内分泌学、糖尿病および代謝内科学
  • 免疫アレルギー学
  • 免疫学
  • 生化学、遺伝学、分子生物学(全般)


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