The placental circulation is crucial for the development of mammalian embryos . The labyrinth layer in the placenta is created by extensive villous branching of the trophoblast and vascularization arising from the embryonic mesoderm. In the labyrinth, materials are exchanged between the maternal and embryonic circulation. Recently, we have found that inositol 1,4,5-trisphosphate (IP3) receptors (IP3Rs) may be required for the placental vascularization.
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