Insulin biosynthesis in neuronal progenitors derived from adult hippocampus and the olfactory bulb

Tomoko Kuwabara, Mohamedi N. Kagalwala, Yasuko Onuma, Yuzuru Ito, Masaki Warashina, Kazuyuki Terashima, Tsukasa Sanosaka, Kinichi Nakashima, Fred H. Gage, Makoto Asashima

研究成果: Article査読

82 被引用数 (Scopus)

抄録

In the present study, we demonstrated that insulin is produced not only in the mammalian pancreas but also in adult neuronal cells derived from the hippocampus and olfactory bulb (OB). Paracrine Wnt3 plays an essential role in promoting the active expression of insulin in both hippocampal and OB-derived neural stem cells. Our analysis indicated that the balance between Wnt3, which triggers the expression of insulin via NeuroD1, and IGFBP-4, which inhibits the original Wnt3 action, is regulated depending on diabetic (DB) status. We also show that adult neural progenitors derived from DB animals retain the ability to give rise to insulin-producing cells and that grafting neuronal progenitors into the pancreas of DB animals reduces glucose levels. This study provides an example of a simple and direct use of adult stem cells from one organ to another, without introducing additional inductive genes. See accompanying article http://dx.doi.org/10.1002/emmm.201100178

本文言語English
ページ(範囲)742-754
ページ数13
ジャーナルEMBO Molecular Medicine
3
12
DOI
出版ステータスPublished - 2011 12月
外部発表はい

ASJC Scopus subject areas

  • 分子医療

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