Inter-institutional survival heterogeneity in chemoradiation therapy for esophageal cancer: Exploratory analysis of the JCOG0303 study

Yasuo Hamamoto, Junki Mizusawa, Hiroshi Katayama, Kenichi Nakamura, Ken Kato, Yasuhiro Tsubosa, Satoshi Ishikura, Hiroyasu Igaki, Masayuki Shinoda, Haruhiko Fukuda, Yuko Kitagawa, Nobutoshi Ando

研究成果: Article査読

3 被引用数 (Scopus)

抄録

It is important to examine variation in the treatment effects of patients with esophageal cancer in order to generalize treatment outcomes.We aimed to investigate the range of prognostic differences among hospitals in the treatment of locally advanced esophageal cancer. The JCOG0303 study compared the efficacy of radiotherapy plus low-dose cisplatin and 5-fluorouracil with that of high-dose cisplatin and 5-fluorouracil for unresectable esophageal cancer. Of 32 institutions participating in the JCOG0303 study, the 18 institutions that enrolled three or more patients were included in this study. We predicted the 1-year survival in each institution by using a mixed-effect model.We found that the predicted 1-year survival in the 18 institutions with three ormore patientswas amedian of 60.9%,with a range of 60.9-60.9%. This study is the first to investigated heterogeneity of survival in patients who received definitive chemoradiotherapy for locally advanced esophageal squamous cell carcinoma.

本文言語English
ページ(範囲)389-392
ページ数4
ジャーナルJapanese journal of clinical oncology
46
4
DOI
出版ステータスPublished - 2016 4 1

ASJC Scopus subject areas

  • 腫瘍学
  • 放射線学、核医学およびイメージング
  • 癌研究

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