抄録
The interaction of transition metal complexes of cationic porphyrins bearing five membered rings, meso-tetrakis(1,2-dimethylpyrazolium-4-yl)porphyrin (MPzP, M=MnIII, NiII, CuII or ZnII), with calf thymus DNA (ctDNA) has been studied. Metalloporphyrins NiPzP and CuPzP are intercalated into the 5′GC3′ step of ctDNA. MnPzP is bound edge-on at the 5′TA3′ step of the minor groove of ctDNA, while ZnPzP is bound face-on at the 5′TA3′ step of the major groove of ctDNA. The binding constants of the metalloporphyrins to ctDNA range from 1.05×105 to 2.66×106 M-1 and are comparable to those of other reported cationic porphyrins. The binding process of the metallopyrazoliumylporphyrins to ctDNA is endothermic and entropically driven. These results have revealed that the kind of central metal ions of metalloporphyrins influences the binding characteristics of the porphyrin to DNA.
| 元の言語 | English |
|---|---|
| ページ（範囲） | 219-228 |
| ページ数 | 10 |
| ジャーナル | Journal of Inorganic Biochemistry |
| 巻 | 85 |
| 発行部数 | 2-3 |
| DOI | |
| 出版物ステータス | Published - 2001 |
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ASJC Scopus subject areas
- Biochemistry
- Inorganic Chemistry
これを引用
Interaction of metallopyrazoliumylporphyrins with calf thymus DNA. / Tjahjono, Daryono H.; Mima, Shunsuke; Akutsu, Takehiro; Yoshioka, Naoki; Inoue, Hidenari.
：: Journal of Inorganic Biochemistry, 巻 85, 番号 2-3, 2001, p. 219-228.研究成果: Article
}
TY - JOUR
T1 - Interaction of metallopyrazoliumylporphyrins with calf thymus DNA
AU - Tjahjono, Daryono H.
AU - Mima, Shunsuke
AU - Akutsu, Takehiro
AU - Yoshioka, Naoki
AU - Inoue, Hidenari
PY - 2001
Y1 - 2001
N2 - The interaction of transition metal complexes of cationic porphyrins bearing five membered rings, meso-tetrakis(1,2-dimethylpyrazolium-4-yl)porphyrin (MPzP, M=MnIII, NiII, CuII or ZnII), with calf thymus DNA (ctDNA) has been studied. Metalloporphyrins NiPzP and CuPzP are intercalated into the 5′GC3′ step of ctDNA. MnPzP is bound edge-on at the 5′TA3′ step of the minor groove of ctDNA, while ZnPzP is bound face-on at the 5′TA3′ step of the major groove of ctDNA. The binding constants of the metalloporphyrins to ctDNA range from 1.05×105 to 2.66×106 M-1 and are comparable to those of other reported cationic porphyrins. The binding process of the metallopyrazoliumylporphyrins to ctDNA is endothermic and entropically driven. These results have revealed that the kind of central metal ions of metalloporphyrins influences the binding characteristics of the porphyrin to DNA.
AB - The interaction of transition metal complexes of cationic porphyrins bearing five membered rings, meso-tetrakis(1,2-dimethylpyrazolium-4-yl)porphyrin (MPzP, M=MnIII, NiII, CuII or ZnII), with calf thymus DNA (ctDNA) has been studied. Metalloporphyrins NiPzP and CuPzP are intercalated into the 5′GC3′ step of ctDNA. MnPzP is bound edge-on at the 5′TA3′ step of the minor groove of ctDNA, while ZnPzP is bound face-on at the 5′TA3′ step of the major groove of ctDNA. The binding constants of the metalloporphyrins to ctDNA range from 1.05×105 to 2.66×106 M-1 and are comparable to those of other reported cationic porphyrins. The binding process of the metallopyrazoliumylporphyrins to ctDNA is endothermic and entropically driven. These results have revealed that the kind of central metal ions of metalloporphyrins influences the binding characteristics of the porphyrin to DNA.
KW - Calf thymus DNA
KW - Cationic pyrazoliumylporphyrin
KW - Metalloporphyrins
KW - Porphyrin-DNA interaction
KW - Thermodynamic parameters
UR - http://www.scopus.com/inward/record.url?scp=0034960984&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034960984&partnerID=8YFLogxK
U2 - 10.1016/S0162-0134(01)00186-6
DO - 10.1016/S0162-0134(01)00186-6
M3 - Article
C2 - 11410242
AN - SCOPUS:0034960984
VL - 85
SP - 219
EP - 228
JO - Journal of Inorganic Biochemistry
JF - Journal of Inorganic Biochemistry
SN - 0162-0134
IS - 2-3
ER -