Interaction of metallopyrazoliumylporphyrins with calf thymus DNA

Daryono H. Tjahjono, Shunsuke Mima, Takehiro Akutsu, Naoki Yoshioka, Hidenari Inoue

研究成果: Article

48 引用 (Scopus)

抄録

The interaction of transition metal complexes of cationic porphyrins bearing five membered rings, meso-tetrakis(1,2-dimethylpyrazolium-4-yl)porphyrin (MPzP, M=MnIII, NiII, CuII or ZnII), with calf thymus DNA (ctDNA) has been studied. Metalloporphyrins NiPzP and CuPzP are intercalated into the 5′GC3′ step of ctDNA. MnPzP is bound edge-on at the 5′TA3′ step of the minor groove of ctDNA, while ZnPzP is bound face-on at the 5′TA3′ step of the major groove of ctDNA. The binding constants of the metalloporphyrins to ctDNA range from 1.05×105 to 2.66×106 M-1 and are comparable to those of other reported cationic porphyrins. The binding process of the metallopyrazoliumylporphyrins to ctDNA is endothermic and entropically driven. These results have revealed that the kind of central metal ions of metalloporphyrins influences the binding characteristics of the porphyrin to DNA.

元の言語English
ページ(範囲)219-228
ページ数10
ジャーナルJournal of Inorganic Biochemistry
85
発行部数2-3
DOI
出版物ステータスPublished - 2001

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Porphyrins
Metalloporphyrins
Bearings (structural)
Coordination Complexes
Transition metals
Metal ions
calf thymus DNA
Metals
Ions
DNA

ASJC Scopus subject areas

  • Biochemistry
  • Inorganic Chemistry

これを引用

Interaction of metallopyrazoliumylporphyrins with calf thymus DNA. / Tjahjono, Daryono H.; Mima, Shunsuke; Akutsu, Takehiro; Yoshioka, Naoki; Inoue, Hidenari.

:: Journal of Inorganic Biochemistry, 巻 85, 番号 2-3, 2001, p. 219-228.

研究成果: Article

Tjahjono, Daryono H. ; Mima, Shunsuke ; Akutsu, Takehiro ; Yoshioka, Naoki ; Inoue, Hidenari. / Interaction of metallopyrazoliumylporphyrins with calf thymus DNA. :: Journal of Inorganic Biochemistry. 2001 ; 巻 85, 番号 2-3. pp. 219-228.
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AU - Yoshioka, Naoki

AU - Inoue, Hidenari

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