Interactions between temperature‐sensitive hydrogel microspheres and granulocytes

Koji Achiha, Rika Ojima, Yuji Kasuya, Keiji Fujimoto, Haruma Kawaguchi

研究成果: Article

18 引用 (Scopus)


Poly(N‐isopropylacrylamide) (PNIPAM) has a low critical solution temperature (LCST) at 32°C in water and the hydrophilicity changes through the LCST. The microspheres whose surface was composed of PNIPAM exhibited phase transition behavior around 32°C. Therefore, the interactions between PNIPAM micropheres and granulocytes depended on the temperature. That is, the oxygen consumption and active oxygen production by cells in contact with PNIPAM‐containing microspheres and adhesion of the microspheres to the cell surface were more enhanced above the LCST of PNIPAM than below it, whereas no significant temperature dependence of cell–microspheres interaction was observed in nonthermosensitive microsphere systems. It was suggested that the function of cells could be controlled with temperature using the temperature‐sensitive microspheres.

ジャーナルPolymers for Advanced Technologies
出版物ステータスPublished - 1995

ASJC Scopus subject areas

  • Polymers and Plastics

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