In this paper, a noble gas sensing system using a large scale integrated resistive sensor array and its interface system is introduced. Accuracy improvement, compared to conventional techniques, was achieved using our proposed opamp output impedance calibration technique. This technique makes it possible to use a low power, weak drivability opamp in the interface circuit. This paper shows the calibration method which reduces the sneak path current error from 83.6% to 1.2% through MATLAB simulations. A prototype system with 1,024 gas sensors integrated in one chip, discrete ICs of opamp, ADCs, and an FPGA was developed, and the effectiveness of the system is demonstrated.