TY - JOUR
T1 - Interferometry in the evaluation of precorneal tear film thickness in dry eye
AU - Hosaka, Eri
AU - Kawamorita, Takushi
AU - Ogasawara, Yuko
AU - Nakayama, Nanami
AU - Uozato, Hiroshi
AU - Shimizu, Kimiya
AU - Dogru, Murat
AU - Tsubota, Kazuo
AU - Goto, Eiki
N1 - Funding Information:
Publication of this article was supported by Grant 18070501 from the Japanese Ministry of Health, Labour and Welfare , Tokyo, Japan. The authors indicate no financial conflict of interest. Involved in Design of study (E.H., T.K., M.D., E.G.); Conduct of study (H.U., K.S., K.T., E.G.); Collection and analysis of data (E.H., T.K., Y.K., N.N.); and Approval of the manuscript (H.U., K.S., M.D., K.T., E.G.). This research followed the tenets of the Declaration of Helsinki and informed consent was obtained from all the subjects after explanation of the nature and possible consequences of the study. Institutional review board approval was obtained at Tsurumi University. This clinical trial was registered to Japan Pharmaceutical Information Center (Tokyo, Japan, Japic CTI-060313).
PY - 2011/1
Y1 - 2011/1
N2 - Purpose To compare tear film thickness between normal subjects and aqueous tear deficiency dry eye patients by tear interferometry. Design Prospective case-control study. Methods Central precorneal tear film thickness was measured noninvasively using an interference thin-film thickness measurement device (Quore MSPA1100; Mamiya-OP). Tear film thickness of 14 eyes from 14 normal subjects and of 28 eyes from 28 aqueous tear deficiency dry eye patients were compared along with noninvasively measured tear meniscus height, DR-1 (Kowa) dry eye severity grading, fluorescein and rose bengal staining scores, tear film break-up time, and Schirmer test results. Among dry eye patients, 13 eyes underwent punctal occlusion, and tear film thickness was compared before and after the surgery. Results Tear film was significantly thinner in dry eye patients (2.0 ± 1.5 μm) than normal subjects (6.0 ± 2.4 μm; P < .0001). Tear film thickness showed good correlation with other dry eye examinations. After punctal occlusion, tear film thickness increased significantly from 1.7 ± 1.5 μm to 4.9 ± 2.8 μm (P = .001) with the improvement of tear meniscus height, fluorescein and rose bengal staining scores, tear film break-up time, and Schirmer test values. Conclusions Interferometric tear film thickness measurement revealed impaired precorneal tear film formation in aqueous tear deficiency dry eyes and was useful for showing the reconstruction of tear film after punctal occlusion surgery. Interferometry of precorneal tear film may be helpful for the evaluation of aqueous tear deficiency in conjunction with other dry eye examinations.
AB - Purpose To compare tear film thickness between normal subjects and aqueous tear deficiency dry eye patients by tear interferometry. Design Prospective case-control study. Methods Central precorneal tear film thickness was measured noninvasively using an interference thin-film thickness measurement device (Quore MSPA1100; Mamiya-OP). Tear film thickness of 14 eyes from 14 normal subjects and of 28 eyes from 28 aqueous tear deficiency dry eye patients were compared along with noninvasively measured tear meniscus height, DR-1 (Kowa) dry eye severity grading, fluorescein and rose bengal staining scores, tear film break-up time, and Schirmer test results. Among dry eye patients, 13 eyes underwent punctal occlusion, and tear film thickness was compared before and after the surgery. Results Tear film was significantly thinner in dry eye patients (2.0 ± 1.5 μm) than normal subjects (6.0 ± 2.4 μm; P < .0001). Tear film thickness showed good correlation with other dry eye examinations. After punctal occlusion, tear film thickness increased significantly from 1.7 ± 1.5 μm to 4.9 ± 2.8 μm (P = .001) with the improvement of tear meniscus height, fluorescein and rose bengal staining scores, tear film break-up time, and Schirmer test values. Conclusions Interferometric tear film thickness measurement revealed impaired precorneal tear film formation in aqueous tear deficiency dry eyes and was useful for showing the reconstruction of tear film after punctal occlusion surgery. Interferometry of precorneal tear film may be helpful for the evaluation of aqueous tear deficiency in conjunction with other dry eye examinations.
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U2 - 10.1016/j.ajo.2010.07.019
DO - 10.1016/j.ajo.2010.07.019
M3 - Article
C2 - 20970770
AN - SCOPUS:78650510270
SN - 0002-9394
VL - 151
SP - 18-23.e1
JO - American Journal of Ophthalmology
JF - American Journal of Ophthalmology
IS - 1
ER -