Intergenerational concordance of brain structure between depressed mothers and their never-depressed daughters

Fusaka Minami, Jinichi Hirano, Ryo Ueda, Akihiro Takamiya, Mika Yamagishi, Kei Kamiya, Masaru Mimura, Bun Yamagata

研究成果: Article査読

抄録

Aim: Parents have significant genetic and environmental influences, which are known as intergenerational effects, on the cognition, behavior, and brain of their offspring. These intergenerational effects are observed in patients with mood disorders, with a particularly strong association of depression between mothers and daughters. The main purpose of our study was to investigate female-specific intergenerational transmission patterns in the human brain among patients with depression and their never-depressed offspring. Methods: We recruited 78 participants from 34 families, which included remitted parents with a history of depression and their never-depressed biological offspring. We used source-based and surface-based morphometry analyses of magnetic resonance imaging data to examine the degree of associations in brain structure between four types of parent-offspring dyads (i.e. mother-daughter, mother-son, father-daughter, and father-son). Results: Using independent component analysis, we found a significant positive correlation of gray matter structure between exclusively the mother-daughter dyads within brain regions located in the default mode and central executive networks, such as the bilateral anterior cingulate cortex, posterior cingulate cortex, precuneus, middle frontal gyrus, middle temporal gyrus, superior parietal lobule, and left angular gyrus. These similar observations were not identified in other three parent-offspring dyads. Conclusions: The current study provides biological evidence for greater vulnerability of daughters, but not sons, in developing depression whose mothers have a history of depression. Our findings extend our knowledge on the pathophysiology of major psychiatric conditions that show sex biases and may contribute to the development of novel interventions targeting high-risk individuals.

本文言語English
ページ(範囲)579-586
ページ数8
ジャーナルPsychiatry and Clinical Neurosciences
76
11
DOI
出版ステータスPublished - 2022 11月

ASJC Scopus subject areas

  • 神経科学(全般)
  • 神経学
  • 臨床神経学
  • 精神医学および精神衛生

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