Interindividual changes in volume of distribution of cefazolin in newborn infants and its prediction based on physiological pharmacokinetic concepts

Yoshiharu Deguchi, Rie Koshida, Emi Nakashima, Reiji Watanabe, Noboru Taniguchi, Fujio Ichimura, Akira Tsuji

研究成果: Article査読

19 被引用数 (Scopus)

抄録

The purpose of this study was to investigate factors affecting the volume of distribution of cefazolin (a β‐lactam antibiotic) in newborn infants with bacterial infections, and to propose a method for predicting the volume of distribution at steady state per body weight (Vdss/BW). Cefazolin and tobramycin (an aminoglycoside) were simultaneously given to newborn infants (aged 2 to 28 d), and plasma concentration‐time data were analyzed on the basis of model‐independent moment analysis. The Vdss/BW values ranged from 0.212 to 0.373 L/kg for cefazolin and from 0.384 to 0.541 L/kg for tobramycin. The unbound fraction of cefazolin in plasma (fp) fluctuated widely, from 0.22 to 0.83, among patients. The Vdss/BW value for cefazolin was characterized by both large extracellular water volume and a remarkable change in fp, and could be predicted as a function of fp using physiological pharmacokinetic concepts. Moreover, interindividual changes in the unconjugated bilirubin:albumin molar ratio were predominantly responsible for the individual variation in the fp values of cefazolin in newborn infants.

本文言語English
ページ(範囲)674-678
ページ数5
ジャーナルJournal of Pharmaceutical Sciences
77
8
DOI
出版ステータスPublished - 1988 8月

ASJC Scopus subject areas

  • 薬科学

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