Interleukin-1β and tumor necrosis factor-α co-operatively enhance a novel trophic activity of astrocytes for pontine cholinergic neurons in vitro

Hiroyuki Kamiguchi, Kazunari Yoshida, Makoto Inaba, Hikaru Sasaki, Mitsuhiro Otani, Shigeo Toya

研究成果: Article査読

3 被引用数 (Scopus)

抄録

Insulin and insulin-like growth factors (IGFs)) are the only known trophic factors for pontine cholinergic neurons. The present study revealed that astrocyte-extract pretreated with IL-1β and TNF-α significantly enhanced choline acetyltransferase (ChAT) activity of the pontine neurons in the presence of a supramaximal dose of insulin, while various trophic factors including IGFs failed to increase the ChAT activity under the same culture conditions, suggesting that IL-1β and TNF-α co-operatively enhanced the expression of a novel trophic factor for pontine cholinergic neurons in astrocytes.

本文言語English
ページ(範囲)43-47
ページ数5
ジャーナルRestorative Neurology and Neuroscience
10
1
DOI
出版ステータスPublished - 1996 7

ASJC Scopus subject areas

  • 神経学
  • 発達神経科学
  • 臨床神経学

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