抄録
The etiology and pathogenesis of inflammatory bowel disease remains an area under intense investigation. Crohn's disease (CD) is characterized by a marked accumulation of activated Th1 type CD4+ T cells and macrophages in inflamed intestinal mucosa. IL-18 is a recently described cytokine that mainly exists in activated macrophages and shares biological activities with IL-12 in driving the development of Th1 type CD4+ T cells by inducing interferon-γ. To clarify the role of IL-18 in intestinal inflammation in CD, we assessed the functional role of IL-18 in regulating intestinal mucosal lymphocytes in human CD and murine CD model.
| 本文言語 | English |
|---|---|
| ページ（範囲） | 37-42 |
| ページ数 | 6 |
| ジャーナル | Digestion |
| 巻 | 63 |
| 号 | SUPPL. 1 |
| DOI | |
| 出版ステータス | Published - 2001 2月 6 |
ASJC Scopus subject areas
- 消化器病学
UN SDG
この成果は、次の持続可能な開発目標に貢献しています
