Interleukin-18 and Crohn's disease

Takanori Kanai, Mamoru Watanabe, Akira Okazawa, Toshiro Sato, Toshifumi Hibi

研究成果: Article

27 引用 (Scopus)


The etiology and pathogenesis of inflammatory bowel disease remains an area under intense investigation. Crohn's disease (CD) is characterized by a marked accumulation of activated Th1 type CD4+ T cells and macrophages in inflamed intestinal mucosa. IL-18 is a recently described cytokine that mainly exists in activated macrophages and shares biological activities with IL-12 in driving the development of Th1 type CD4+ T cells by inducing interferon-γ. To clarify the role of IL-18 in intestinal inflammation in CD, we assessed the functional role of IL-18 in regulating intestinal mucosal lymphocytes in human CD and murine CD model.

発行部数SUPPL. 1
出版物ステータスPublished - 2001 2 6

ASJC Scopus subject areas

  • Gastroenterology

フィンガープリント Interleukin-18 and Crohn's disease' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

  • これを引用

    Kanai, T., Watanabe, M., Okazawa, A., Sato, T., & Hibi, T. (2001). Interleukin-18 and Crohn's disease. Digestion, 63(SUPPL. 1), 37-42.