Interleukin-4 and IgE in seasonal allergic conjunctivitis

Hiroshi Fujishima, Jun Shimazaki, Tsutomu Takeuchi, Ichiro Saito, Kazuo Tsubota

研究成果: Article査読

16 被引用数 (Scopus)

抄録

We measured interleukin-4 (IL-4) and IgE to study their presence in patients with seasonal allergic conjunctivitis. Twenty patients and 10 normal subjects were enrolled in this study, and their brush cytology samples and peripheral blood lymphocytes (PBL) were cultured for 3 or 24 h. IL-4 levels were measured using ELISA in the supernatants. Measurements of serum IgE were also performed. IL-4 was detected in 4 of 40 brush cytology samples and 10 of 40 PBL samples, but not from the controls. IL-4 positivity rate of patients was significantly higher than normal in 24-hour cultured PBL (p = 0.03). Patients’ serum IgE was also significantly higher (p = 0.006). IL-4 may contribute to the development of seasonal allergic conjunctivitis.

本文言語English
ページ(範囲)325-328
ページ数4
ジャーナルOphthalmologica
210
6
DOI
出版ステータスPublished - 1996 1月 1
外部発表はい

ASJC Scopus subject areas

  • 眼科学
  • 感覚系

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