Interleukin 4 promotes the growth of tumor-infiltrating lymphocytes cytotoxic for human autologous melanoma

Yutaka Kawakami, S. A. Rosenberg, M. T. Lotze

研究成果: Article

150 引用 (Scopus)

抄録

Addition of IL-4 (1,000 U/ml) to either high or low concentrations of IL-2 augmented tumor-infiltrating (TIL) growth from human melanoma. Weekly restimulation with irradiated tumor cells in conjunction with IL-4 allowed enhanced growth of TIL. With low-dose IL-2 (10 U/ml) and IL-4, expanded TIL had little cytolytic activity against Daudi or allogeneic tumors. Further, IL-4 augmented the total lytic activity against autologous tumors in most cases. With high-dose IL-2 (1,000 U/ml), IL-4 addition decreased nonspecific killing activity against Daudi or allogeneic melanomas in many cases, and reciprocally augmented cytolytic activity against the autologous melanoma in many cases. This suggests the possible use of IL-4 in cancer therapy, especially in adoptive cellular immunotherapy using TIL or in conjunction with IL-2 administration.

元の言語English
ページ(範囲)2183-2191
ページ数9
ジャーナルJournal of Experimental Medicine
168
発行部数6
出版物ステータスPublished - 1988
外部発表Yes

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Tumor-Infiltrating Lymphocytes
Interleukin-4
Melanoma
Growth
Interleukin-2
Neoplasms
Interleukin-1
Adoptive Immunotherapy
Interleukin-10

ASJC Scopus subject areas

  • Immunology

これを引用

Interleukin 4 promotes the growth of tumor-infiltrating lymphocytes cytotoxic for human autologous melanoma. / Kawakami, Yutaka; Rosenberg, S. A.; Lotze, M. T.

:: Journal of Experimental Medicine, 巻 168, 番号 6, 1988, p. 2183-2191.

研究成果: Article

Kawakami, Yutaka ; Rosenberg, S. A. ; Lotze, M. T. / Interleukin 4 promotes the growth of tumor-infiltrating lymphocytes cytotoxic for human autologous melanoma. :: Journal of Experimental Medicine. 1988 ; 巻 168, 番号 6. pp. 2183-2191.
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