Interleukin-6-producing intravascular large b-cell lymphoma with lymphadenopathy mimicking the histology of multicentric castleman disease

Kohei Shiroshita, Taku Kikuchi, Mikio Okayama, Hidenori Kasahara, Takahiro Kamiya, Takayuki Shimizu, Nozomu Kurose, Yasufumi Masaki, Shinichiro Okamoto

研究成果: Article査読

抄録

An inguinal lymph node biopsy of a woman with a one-month history of a progressive fever, fatigue, dyspnea, skin rash, and lymphadenopathy revealed a well-preserved basic structure, hyperplastic germinal centers, and an interfollicular region containing polyclonal plasma cell sheets, suggesting plasma cell-type multicentric Castleman disease (MCD). We initiated prednisolone and anti-interleukin (IL)-6 antibody (tocilizumab), without success. A biopsy specimen re-evaluation detected CD20-positive atypical large B cells infiltrating the small vessels within and around the lymph node and its capsule. We diagnosed her with intravascular large B-cell lymphoma (IVLBCL). Lymphoma cells were weakly positive for IL-6 by immunohistochemical staining. IL-6 from lymphoma cells may have caused the MCD-like presentation as a paraneoplastic etiology. Malignant lymphoma should be excluded before diagnosing MCD.

本文言語English
ページ(範囲)3061-3065
ページ数5
ジャーナルInternal Medicine
59
23
DOI
出版ステータスPublished - 2020 12 1

ASJC Scopus subject areas

  • Internal Medicine

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