Intermittent Granulocyte and Monocyte Apheresis Versus Mercaptopurine for Maintaining Remission of Ulcerative Colitis: A Pilot Study

Atsushi Sakuraba, Toshiro Sato, Yuichi Morohoshi, Katsuyoshi Matsuoka, Susumu Okamoto, Nagamu Inoue, Hiromasa Takaishi, Haruhiko Ogata, Yasushi Iwao, Toshifumi Hibi

研究成果: Article

6 引用 (Scopus)

抄録

The effect of granulocyte and monocyte adsorption apheresis (GMA) on prevention of relapse of ulcerative colitis (UC) is not clear. This was a pilot open-labeled, prospective, randomized, unblinded study to compare the tolerability and efficacy of intermittent GMA (once every 2weeks) with mercaptopurine to maintain remission of UC. Twenty-one patients with UC, who had achieved remission by induction therapies were randomly assigned to receive either intermittent GMA (N=10) or oral mercaptopurine (0.5mg/kg per day; N=11). The study period was 24months. The rate of the patients maintaining remission and the incidences of adverse effects were compared between the two groups. At 24months, seven of 10 patients (70.0%) on intermittent GMA and seven of 11 patients (63.6%, P=1.00) on oral mercaptopurine were still in remission. Three patients relapsed in each group. One patient taking mercaptopurine, but none receiving intermittent GMA, dropped out because of adverse effects. Intermittent therapy with GMA was well tolerated and a substantial proportion of patients maintained remission. Intermittent GMA therapy in maintaining remission of UC merits further investigation.

元の言語English
ページ(範囲)213-218
ページ数6
ジャーナルTherapeutic Apheresis and Dialysis
16
発行部数3
DOI
出版物ステータスPublished - 2012 6

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6-Mercaptopurine
Blood Component Removal
Ulcerative Colitis
Granulocytes
Adsorption
Monocytes
Remission Induction
Secondary Prevention
Therapeutics
Incidence

ASJC Scopus subject areas

  • Hematology
  • Nephrology

これを引用

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abstract = "The effect of granulocyte and monocyte adsorption apheresis (GMA) on prevention of relapse of ulcerative colitis (UC) is not clear. This was a pilot open-labeled, prospective, randomized, unblinded study to compare the tolerability and efficacy of intermittent GMA (once every 2weeks) with mercaptopurine to maintain remission of UC. Twenty-one patients with UC, who had achieved remission by induction therapies were randomly assigned to receive either intermittent GMA (N=10) or oral mercaptopurine (0.5mg/kg per day; N=11). The study period was 24months. The rate of the patients maintaining remission and the incidences of adverse effects were compared between the two groups. At 24months, seven of 10 patients (70.0{\%}) on intermittent GMA and seven of 11 patients (63.6{\%}, P=1.00) on oral mercaptopurine were still in remission. Three patients relapsed in each group. One patient taking mercaptopurine, but none receiving intermittent GMA, dropped out because of adverse effects. Intermittent therapy with GMA was well tolerated and a substantial proportion of patients maintained remission. Intermittent GMA therapy in maintaining remission of UC merits further investigation.",
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AU - Sato, Toshiro

AU - Morohoshi, Yuichi

AU - Matsuoka, Katsuyoshi

AU - Okamoto, Susumu

AU - Inoue, Nagamu

AU - Takaishi, Hiromasa

AU - Ogata, Haruhiko

AU - Iwao, Yasushi

AU - Hibi, Toshifumi

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