Intermittent hypoxia induces disturbances in craniofacial growth and defects in craniofacial morphology

Shuji Oishi, Yasuhiro Shimizu, Jun Hosomichi, Yoichiro Kuma, Hisashi Nagai, Hideyuki Maeda, Risa Usumi-Fujita, Sawa Kaneko, Chisa Shitano, Jun Ichi Suzuki, Ken Ichi Yoshida, Takashi Ono

研究成果: Article査読

18 被引用数 (Scopus)

抄録

Objectives To investigate intermittent hypoxia (IH) induced changes in craniofacial morphology and bone mineral density (BMD) in the mandible of growing rats. Design Seven-week-old male Sprague-Dawley rats were exposed to IH for 4 days or 3 weeks. Sham-operated rats simultaneously breathed room air. Lateral and transverse cephalometric radiographs of the craniofacial region were obtained, and the linear distances between cephalometric landmarks were statistically analyzed. BMD and bone microstructure of the mandible were evaluated using micro-computed tomography (micro-CT). Results Cephalometric analyses demonstrated that exposure to IH only in the two groups for 3 weeks decreased the size of the mandibular and viscerocranial bones, but not that of the neurocranial bones, in early adolescent rats. These findings are consistent with upper airway narrowing and obstructive sleep apnea (OSA). Micro-CT showed that IH increased the BMD in the cancellous bone of the mandibular condyle and the inter-radicular alveolar bone in the mandibular first molar (M1) region. Conclusions This study is the first to identify growth retardation of the craniofacial bones in an animal model of sleep apnea. Notably, 3 weeks of IH can induce multiple changes in the bones around the upper airway in pubertal rats, which can enhance upper airway narrowing and the development of OSA. The reproducibility of these results supports the validity and usefulness of this model. These findings also emphasize the critical importance of morphometric evaluation of patients with OSA.

本文言語English
ページ(範囲)115-124
ページ数10
ジャーナルArchives of Oral Biology
61
DOI
出版ステータスPublished - 2016 1月 1

ASJC Scopus subject areas

  • 耳鼻咽喉科学
  • 歯科学(全般)
  • 細胞生物学

フィンガープリント

「Intermittent hypoxia induces disturbances in craniofacial growth and defects in craniofacial morphology」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル