Interstitial lung disease in polymyositis and dermatomyositis

Michito Hirakata, Sonoko Nagai

研究成果: Review article査読

124 被引用数 (Scopus)

抄録

Interstitial lung disease (ILD) is common in patients with polymyositis (PM) and dermatomyositis (DM), and is a major cause of morbidity. Although its cause is unknown, it is known to be closely associated with autoimmune disorders. Its manifestation has been found to be quite heterogeneous, as demonstrated by the differences among PM/DM patients in their immunologic profiles and histopathologic findings, which suggest variations in immunopathogenetic mechanisms. We review the clinicopathologic and immunologic findings in ILD associated with PM/DM, and discuss recent advances in classification, autoantibodies, and treatment. The most critical issues are to clarify the immunopathogenesis of severe forms of ILD, such as rapidly progressive ILD associated with amyopathic DM, and to establish the most appropriate therapy. (C) 2000 Lippincott Williams and Wilkins, Inc.

本文言語English
ページ(範囲)501-508
ページ数8
ジャーナルCurrent Opinion in Rheumatology
12
6
DOI
出版ステータスPublished - 2000 11月 9

ASJC Scopus subject areas

  • リウマチ学

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