Intestinal and peri-tumoral lymphatic endothelial cells are resistant to radiation-induced apoptosis

Hoon Ki Sung, Tohru Morisada, Chung Hyun Cho, Yuichi Oike, Jayhun Lee, Eon Ki Sung, Jae Hoon Chung, Toshio Suda, Gou Young Koh

研究成果: Article査読

12 被引用数 (Scopus)

抄録

Radiation therapy is a widely used cancer treatment, but it is unable to completely block cancer metastasis. The lymphatic vasculature serves as the primary route for metastatic spread, but little is known about how lymphatic endothelial cells respond to radiation. Here, we show that lymphatic endothelial cells in the small intestine and peri-tumor areas are highly resistant to radiation injury, while blood vessel endothelial cells in the small intestine are relatively sensitive. Our results suggest the need for alternative therapeutic modalities that can block lymphatic endothelial cell survival, and thus disrupt the integrity of lymphatic vessels in peri-tumor areas.

本文言語English
ページ(範囲)545-551
ページ数7
ジャーナルBiochemical and Biophysical Research Communications
345
2
DOI
出版ステータスPublished - 2006 6 30

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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