Intestinal bile acid composition modulates prohormone convertase 1β (PC1/3) expression and consequent GLP-1 production in male mice

研究成果: Article査読

15 被引用数 (Scopus)

抄録

Besides an established medication for hypercholesterolemia, bile acid binding resins (BABRs) present antidiabetic effects. Although the mechanisms underlying these effects are still enigmatic, glucagon-like peptide-1 (GLP-1) appearstobe involved.Inadditiontoafew reported mechanisms, we propose prohormone convertase 1β (PC1β), an essential enzyme of GLP-1 production, as a potent molecule in the GLP-1 release induced by BABRs. In our study, the BABR colestimide leads to a bile acid-specific G protein-coupled receptor TGR5-dependent induction of PC1/3; gene expression. Here, we focused on the alteration of intestinal bile acid composition and consequent increase of total TGR5 agonistic activity to explain the TGR5 activation. Furthermore, we demonstrate that nuclear factor of activated T cells mediates the TGR5-triggered PC1/3 gene expression. Altogether, our data indicate that the TGR5-dependent intestinal PC1/3 gene expression supports the BABR-stimulated GLP-1 release. We also propose a combination of BABR and dipeptidyl peptidase-4 inhibitor in the context of GLP-1-based antidiabetic therapy.

本文言語English
ページ(範囲)1071-1081
ページ数11
ジャーナルEndocrinology
157
3
DOI
出版ステータスPublished - 2016 3

ASJC Scopus subject areas

  • 内分泌学

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