Intestinal commensal microbes as immune modulators

Ivaylo I. Ivanov, Kenya Honda

研究成果: Article

172 引用 (Scopus)

抄録

Commensal bacteria are necessary for the development and maintenance of a healthy immune system. Harnessing the ability of microbiota to affect host immunity is considered an important therapeutic strategy for many mucosal and nonmucosal immune-related conditions, such as inflammatory bowel diseases (IBDs), celiac disease, metabolic syndrome, diabetes, and microbial infections. In addition to well-established immunostimulatory effects of the microbiota, the presence of individual mutualistic commensal bacteria with immunomodulatory effects has been described. These organisms are permanent members of the commensal microbiota and affect host immune homeostasis in specific ways. Identification of individual examples of such immunomodulatory commensals and understanding their mechanisms of interaction with the host will be invaluable in designing therapeutic strategies to reverse intestinal dysbiosis and recover immunological homeostasis.

元の言語English
ページ(範囲)496-508
ページ数13
ジャーナルCell Host and Microbe
12
発行部数4
DOI
出版物ステータスPublished - 2012 10 18
外部発表Yes

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Microbiota
Homeostasis
Dysbiosis
Bacteria
Celiac Disease
Inflammatory Bowel Diseases
Immune System
Immunity
Maintenance
Therapeutics
Infection

ASJC Scopus subject areas

  • Immunology and Microbiology(all)
  • Cancer Research
  • Molecular Biology

これを引用

Intestinal commensal microbes as immune modulators. / Ivanov, Ivaylo I.; Honda, Kenya.

:: Cell Host and Microbe, 巻 12, 番号 4, 18.10.2012, p. 496-508.

研究成果: Article

Ivanov, Ivaylo I. ; Honda, Kenya. / Intestinal commensal microbes as immune modulators. :: Cell Host and Microbe. 2012 ; 巻 12, 番号 4. pp. 496-508.
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