Intracellular efavirenz levels in peripheral blood mononuclear cells from human immunodeficiency virus-infected individuals

Rie Tanaka, Hideji Hanabusa, Ei Kinai, Naoki Hasegawa, Masayoshi Negishi, Shingo Kato

研究成果: Article

15 引用 (Scopus)

抄録

We describe a novel method for isolating plasma-free peripheral blood mononuclear cells retaining intracellular efavirenz. Quantification of efavirenz in 13 human immunodeficiency virus-infected patients by liquid chromatography-tandem mass spectrometry showed a higher correlation of intracellular levels with unbound plasma levels (accumulation ratio, 1,190) than with total plasma levels.

元の言語English
ページ(範囲)782-785
ページ数4
ジャーナルAntimicrobial Agents and Chemotherapy
52
発行部数2
DOI
出版物ステータスPublished - 2008 2

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efavirenz
Blood Cells
HIV
Tandem Mass Spectrometry
Liquid Chromatography

ASJC Scopus subject areas

  • Pharmacology (medical)

これを引用

Intracellular efavirenz levels in peripheral blood mononuclear cells from human immunodeficiency virus-infected individuals. / Tanaka, Rie; Hanabusa, Hideji; Kinai, Ei; Hasegawa, Naoki; Negishi, Masayoshi; Kato, Shingo.

:: Antimicrobial Agents and Chemotherapy, 巻 52, 番号 2, 02.2008, p. 782-785.

研究成果: Article

Tanaka, Rie ; Hanabusa, Hideji ; Kinai, Ei ; Hasegawa, Naoki ; Negishi, Masayoshi ; Kato, Shingo. / Intracellular efavirenz levels in peripheral blood mononuclear cells from human immunodeficiency virus-infected individuals. :: Antimicrobial Agents and Chemotherapy. 2008 ; 巻 52, 番号 2. pp. 782-785.
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