Intracerebroventricular injection of brain natriuretic peptide inhibits vasopressin secretion in conscious rats

T. Yamada, K. Nakao, H. Itoh, G. Shirakami, K. Kangawa, N. Minamino, H. Matsuo, H. Imura

研究成果: Article査読

54 被引用数 (Scopus)

抄録

The effect of intracerebroventricular (i.c.v.) injection of brain natriuretic peptide (BNP), a novel peptide purified from the porcine brain, on arginine vasopressin (AVP) secretion was studied in conscious, unrestrained rats and was compared with that of atrial natriuretic polypeptide (ANP). I.c.v. administration of BNP (0.01, 0.1 or 1 nmol) significantly inhibited basal AVP secretion and the effect of BNP was comparable to that of ANP. The AVP secretion induced by i.c.v. injection of angiotensin II (0.1 nmol) was significantly suppressed by the pretreatment with BNP (0.1 or 1 nmol). These results suggest that BNP is involved in the central control of AVP secretion either alone or in combination with brain ANP.

本文言語English
ページ(範囲)223-228
ページ数6
ジャーナルNeuroscience Letters
95
1-3
DOI
出版ステータスPublished - 1988 12月 19
外部発表はい

ASJC Scopus subject areas

  • 神経科学(全般)

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