Intramolecular nitrile oxide-alkene cycloaddition of sugar derivatives with unmasked hydroxyl group(s)

Tony K.M. Shing, Wai F. Wong, Hau M. Cheng, Wun S. Kwok, King H. So

研究成果: Article

40 引用 (Scopus)

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(Chemical Equation Presented) Intramolecular nitrile oxide-alkene cycloaddition (INOC) of sugar derivatives with one to four free hydroxyl group(s) is reported. The INOC reaction, using chloramine-T, in the presence of silica gel, to generate nitrile oxides from oximes, proceeded smoothly to afford five- or six-membered carbocycles in good to excellent yields. This new methodology alleviates protection/deprotection steps and makes the synthetic route shorter and more efficient.

元の言語English
ページ(範囲)753-756
ページ数4
ジャーナルOrganic Letters
9
発行部数5
DOI
出版物ステータスPublished - 2007 3 1

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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