Intrinsic and extrinsic determinants regulating cell fate decision in developing nervous system

Masataka Okabe, Kazunobu Sawamoto, Takao Imai, Shin ichi Sakakibara, Shingo Yoshikawa, Hideyuki Okano

研究成果: Article査読

11 被引用数 (Scopus)

抄録

Cell fate in the nervous system is determined by environmental signals and/or heredity. They can be referred to as extrinsic and intrinsic determinants, respectively. The molecular and cellular mechanisms underlying these processes are well conserved from invertebrates to vertebrates. We have identified both types of determinants through the intensive screening of P-element-induced Drosophila mutants affected in neural development. As a member of the first category, argos gene product which regulates cell-cell interaction in the developing nervous system gives a good example. As a member of the second category, we refer to Drosophila musashi gene encoding a neural RNA-binding protein. The functions of these gene products and application to the mammalian nervous system will be discussed.

本文言語English
ページ(範囲)9-16
ページ数8
ジャーナルDevelopmental Neuroscience
19
1
DOI
出版ステータスPublished - 1996 1月
外部発表はい

ASJC Scopus subject areas

  • 神経学
  • 発達神経科学

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