Inverse association between serum adiponectin level and transaminase activities in Japanese male workers

Hirokazu Yokoyama, Hiroshi Hirose, Hideki Ohgo, Ikuo Saito

研究成果: Article

48 引用 (Scopus)

抄録

Background/Aims Since a novel polypeptide named adiponectin was shown to prevent the development of steatosis and steatohepatitis in animal models, we studied whether it was also possible in a clinical situation. Methods Associations between serum adiponectin levels and serum transaminase activities were studied in 791 Japanese males who were not heavy drinkers, and had no autoimmune or HBV- or HCV-induced liver diseases. Results Various markers of metabolic diseases including levels of body mass index (BMI), serum triglyceride, total cholesterol, and insulin resistance assessed by the homeostasis model were significantly higher in subjects with increased transaminase activities when compared to those with normal activities. Single regression analyses demonstrated that the logarithmic serum adiponectin level was inversely correlated with the levels of logarithmic serum AST (r=-0.229, P<0.0001), ALT (r=-0.305, P<0.0001), and γGTP (r=-0.278, P<0.0001). Even in multiple regression analyses in which subjects' age and levels of BMI, serum triglyceride, total cholesterol, and insulin resistance were adjusted, the inverse correlations were significant (P=0.0426, 0.0332, and 0.0011, respectively). Conclusions Hypoadiponectinemia may worsen liver diseases associated with metabolic diseases in clinical cases. In addition to aggravation of insulin resistance and hyperlipidemia, some hypoadiponectinemia specific mechanisms may stand behind the association.

元の言語English
ページ(範囲)19-24
ページ数6
ジャーナルJournal of Hepatology
41
発行部数1
DOI
出版物ステータスPublished - 2004 7

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Adiponectin
Transaminases
Serum
Insulin Resistance
Metabolic Diseases
Liver Diseases
Triglycerides
Body Mass Index
Cholesterol
Regression Analysis
Fatty Liver
Guanosine Triphosphate
Hyperlipidemias
Homeostasis
Animal Models
Peptides

ASJC Scopus subject areas

  • Gastroenterology

これを引用

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