Inversed relationship between CD44 variant and c-Myc due to oxidative stress-induced canonical Wnt activation

Go J. Yoshida, Hideyuki Saya

研究成果: Article査読

57 被引用数 (Scopus)

抄録

Cancer stem-like cells express high amount of CD44 variant8-10 which protects cancer cells from redox stress. We have demonstrated by immunohistochemical analysis and Western blotting, and reverse-transcription polymerase chain reaction, that CD44 variant8-10 and c-Myc tend to show the inversed expression manner in gastric cancer cells. That is attributable to the oxidative stress-induced canonical Wnt activation, and furthermore, the up-regulation of the downstream molecules, one of which is oncogenic c-Myc, is not easily to occur in CD44 variant-positive cancer cells. We have also found out that CD44v8-10 expression is associated with the turn-over of the c-Myc with the experiments using gastric cancer cell lines. This cannot be simply explained by the model of oxidative stress-induced Wnt activation. CD44v8-10-positive cancer cells are enriched at the invasive front. Tumor tissue at the invasive area is considered to be composed of heterogeneous cellular population; dormant cancer stem-like cells with CD44v8-10 high/ Fbw7 high/ c-Myc low and proliferative cancer stem-like cells with CD44v8-10 high/ Fbw7 low/ c-Myc high.

本文言語English
ページ(範囲)622-627
ページ数6
ジャーナルBiochemical and Biophysical Research Communications
443
2
DOI
出版ステータスPublished - 2014 1 10

ASJC Scopus subject areas

  • 生物理学
  • 生化学
  • 分子生物学
  • 細胞生物学

フィンガープリント

「Inversed relationship between CD44 variant and c-Myc due to oxidative stress-induced canonical Wnt activation」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル