Inversion of enantioselectivity of asymmetric biocatalytic decarboxylation by site-directed mutagenesis based on the reaction mechanism

Yoichiro Ijima, Kaori Matoishi, Yosuke Terao, Nobuhide Doi, Hiroshi Yanagawa, Hiromichi Ohta

研究成果: Article

52 引用 (Scopus)

抄録

The introduction of two mutations (G74C/C188S) based on the estimated reaction mechanism resulted in the inversion of enantioselectivity of arylmalonate decarboxylase, which catalyses the asymmetric decarboxylation of arylmethylmalonate to give optically active arylpropionate.

元の言語English
ページ(範囲)877-879
ページ数3
ジャーナルChemical Communications
発行部数7
DOI
出版物ステータスPublished - 2005 2 21

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Mutagenesis
Enantioselectivity
malonate decarboxylase
Decarboxylation

ASJC Scopus subject areas

  • Chemistry(all)

これを引用

Inversion of enantioselectivity of asymmetric biocatalytic decarboxylation by site-directed mutagenesis based on the reaction mechanism. / Ijima, Yoichiro; Matoishi, Kaori; Terao, Yosuke; Doi, Nobuhide; Yanagawa, Hiroshi; Ohta, Hiromichi.

:: Chemical Communications, 番号 7, 21.02.2005, p. 877-879.

研究成果: Article

Ijima, Yoichiro ; Matoishi, Kaori ; Terao, Yosuke ; Doi, Nobuhide ; Yanagawa, Hiroshi ; Ohta, Hiromichi. / Inversion of enantioselectivity of asymmetric biocatalytic decarboxylation by site-directed mutagenesis based on the reaction mechanism. :: Chemical Communications. 2005 ; 番号 7. pp. 877-879.
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