Investigation of β-lactam antibiotic-induced vancomycin-resistant MRSA (BIVR)

Hideaki Hanaki, Yoshio Yamaguchi, Chie Yanagisawa, Kazuaki Uehara, Hidehito Matsui, Yukie Yamaguchi, Yasuko Hososaka, Kazunari Barada, Fumiko Sakai, Yasuko Itabashi, Shinsuke Ikeda, Koichiro Atsuda, Haruo Tanaka, Takashi Inamatsu, Ariaki Nagayama, Keisuke Sunakawa

研究成果: Article査読

12 被引用数 (Scopus)

抄録

We could not detect hetero-vancomycin-intermediate resistant Staphylococcus aureus (hetero-VISA), according to the definition of hetero-VISA, from the clinical isolates of 140 methicillin-resistant S. aureus (MRSA) strains. However, 15 β-lactam antibiotic-induced vancomycin-resistant MRSA (BIVR) strains were detected from the same strains. We screened 1882 MRSA clinical isolates obtained in 2002 from 21 institutes throughout Japan. The detection rate of blood-isolated BIVR was 12.6% (19/151), and that of nonblood-isolated BIVR was 4.9% (85/1731; P < 0.001; χ2 test). Uridine-diphosphate-N-acetylmuramyl-L-alanyl-D-isoglutamyl-L-lysine, used as the peptidoglycan material of S. aureus, showed the same results as β-lactam antibiotics in BIVR.

本文言語English
ページ(範囲)104-106
ページ数3
ジャーナルJournal of Infection and Chemotherapy
11
2
DOI
出版ステータスPublished - 2005 4月
外部発表はい

ASJC Scopus subject areas

  • 微生物学(医療)
  • 感染症
  • 薬理学(医学)

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