Investigation of Spatiotemporal Profiles of Single-Pulse TMS-Evoked Potentials with Active Stimulation Compared with a Novel Sham Condition

Mayuko Takano, Masataka Wada, Reza Zomorrodi, Keita Taniguchi, Xuemei Li, Shiori Honda, Yui Tobari, Yu Mimura, Shinichiro Nakajima, Ryosuke Kitahata, Masaru Mimura, Zafiris J. Daskalakis, Daniel M. Blumberger, Yoshihiro Noda

研究成果: Article査読

抄録

Identifying genuine cortical stimulation-elicited electroencephalography (EEG) is crucial for improving the validity and reliability of neurophysiology using transcranial magnetic stimulation (TMS) combined with EEG. In this study, we evaluated the spatiotemporal profiles of single-pulse TMS-elicited EEG response administered to the left dorsal prefrontal cortex (DLPFC) in 28 healthy participants, employing active and sham stimulation conditions. We hypothesized that the early component of TEP would be activated in active stimulation compared with sham stimulation. We specifically analyzed the (1) stimulus response, (2) frequency modulation, and (3) phase synchronization of TMS–EEG data at the sensor level and the source level. Compared with the sham condition, the active condition induced a significant increase in TMS-elicited EEG power in the 30–60 ms time interval in the stimulation area at the sensor level. Furthermore, in the source-based analysis, the active condition induced significant increases in TMS-elicited response in the 30–60 ms compared with the sham condition. Collectively, we found that the active condition could specifically activate the early component of TEP compared with the sham condition. Thus, the TMS–EEG method that was applied to the DLPFC could detect the genuine neurophysiological cortical responses by properly handling potential confounding factors such as indirect response noises.

本文言語English
論文番号814
ジャーナルBiosensors
12
10
DOI
出版ステータスPublished - 2022 10月

ASJC Scopus subject areas

  • 分析化学
  • バイオテクノロジー
  • 生体医工学
  • 器械工学
  • 工学(その他)
  • 臨床生化学

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