Involvement of astrocytes in neurovascular communication

M. Nuriya, H. Hirase

研究成果: Conference contribution

22 被引用数 (Scopus)

抄録

The vascular interface of the brain is distinct from that of the peripheral tissue in that astrocytes, the most numerous glial cell type in the gray matter, cover the vasculature with their endfeet. This morphological feature of the gliovascular junction has prompted neuroscientists to suggest possible functional roles of astrocytes including astrocytic modulation of the vasculature. Additionally, astrocytes develop an intricate morphology that intimately apposes neuronal synapses, making them an ideal cellular mediator of neurovascular coupling. In this article, we first introduce the classical anatomical and physiological findings that led to the proposal of various gliovascular interaction models. Next, we touch on the technological advances in the past few decades that enabled investigations and evaluations of neuro-glio-vascular interactions in situ. We then review recent experimental findings on the roles of astrocytes in neurovascular coupling from the viewpoints of intra- and intercellular signalings in astrocytes.

本文言語English
ホスト出版物のタイトルNew Horizons in Neurovascular Coupling
ホスト出版物のサブタイトルA Bridge Between Brain Circulation and Neural Plasticity, 2016
編集者Kazuto Masamoto, Hajime Hirase, Katsuya Yamada
出版社Elsevier B.V.
ページ41-62
ページ数22
ISBN(印刷版)9780444637048
DOI
出版ステータスPublished - 2016

出版物シリーズ

名前Progress in Brain Research
225
ISSN(印刷版)0079-6123
ISSN(電子版)1875-7855

ASJC Scopus subject areas

  • 神経科学(全般)

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