Involvement of hydrogen peroxide production in erbstatin-induced apoptosis in human small cell lung carcinoma cells

Siro Simizu, Masaya Imoto, Noriyuki Masuda, Minoru Takada, Kazuo Umezawa

研究成果: Article査読

50 被引用数 (Scopus)

抄録

Tyrosine kinase inhibitor, erbstatin, induced morphological apoptosis and DNA fragmentation in human small cell lung carcinoma (SCLC) cells. Erbstatin-induced apoptosis was inhibited by antioxidants, whereas erb- statin-inhibited tyrosine phosphorylation was not affected by them. Erbstatin was shown by means of flow cytometry to induce hydrogen peroxide generation. Furthermore, hydrogen peroxide induced morphological apoptosis and DNA fragmentation in the SCLC cells. We also demonstrated that erbstatin-induced hydrogen peroxide production and DNA fragmentation were partially suppressed by inhibition of protein synthesis. Thus, erbstatin-induced apoptosis would be due to hydrogen peroxide generation via newly synthesized protein.

本文言語English
ページ(範囲)4978-4982
ページ数5
ジャーナルCancer Research
56
21
出版ステータスPublished - 1996 11 1

ASJC Scopus subject areas

  • 腫瘍学
  • 癌研究

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