Involvement of mast cells in systemic sclerosis

Sonosuke Yukawa, Kunihiro Yamaoka, Norifumi Sawamukai, Shohei Shimajiri, Kazuyoshi Saito, Yoshiya Tanaka

研究成果: Review article査読

4 被引用数 (Scopus)

抄録

Systemic sclerosis is characterized by tissue fibrosis, obliterative microangiopathy and immune abnormalities. The etiology of SSc is largely unknown and is known to be resistant to existing corticosteroid and immunosuppressive drugs. Therefore, establishment of a treatment strategy especially for SSc patients with organ involvement is strongly desired. Mast cells are widely recognized as effector cells in allergic disorders and other IgE-mediated immune responses. However, recently, mast cells have become known to play a role in bridging innate immunity and adaptive immunity. Additionally, there is growing evidence of mast cell to be involved in pathogenesis of rheumatoid arthritis, and is expected as a novel therapeutic target.We describe here the role of mast cell in SSc pathology and suggest as a novel therapeutic target.

本文言語English
ページ(範囲)81-86
ページ数6
ジャーナルJapanese Journal of Clinical Immunology
33
2
DOI
出版ステータスPublished - 2010

ASJC Scopus subject areas

  • 免疫アレルギー学
  • 免疫学

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