IPS cell technologies: Significance and applications to CNS regeneration and disease

Hideyuki Okano, Shinya Yamanaka

研究成果: Article査読

169 被引用数 (Scopus)

抄録

In 2006, we demonstrated that mature somatic cells can be reprogrammed to a pluripotent state by gene transfer, generating induced pluripotent stem (iPS) cells. Since that time, there has been an enormous increase in interest regarding the application of iPS cell technologies to medical science, in particular for regenerative medicine and human disease modeling. In this review article, we outline the current status of applications of iPS technology to cell therapies (particularly for spinal cord injury), as well as neurological disease-specific iPS cell research (particularly for Parkinson's disease and Alzheimer's disease). Finally, future directions of iPS cell research are discussed including a) development of an accurate assay system for disease-associated phenotypes, b) demonstration of causative relationships between genotypes and phenotypes by genome editing, c) application to sporadic and common diseases, and d) application to preemptive medicine.

本文言語English
論文番号22
ジャーナルMolecular brain
7
1
DOI
出版ステータスPublished - 2014 3月 31

ASJC Scopus subject areas

  • 分子生物学
  • 細胞および分子神経科学

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