Iridium-catalyzed reductive nucleophilic addition to tertiary amides

Yoshito Takahashi, Takaaki Sato, Noritaka Chida

研究成果: Review article査読

11 被引用数 (Scopus)

抄録

This article describes the development of an iridium-catalyzed reductive nucleophilic addition to tertiary amides. A conspicuous feature of this reaction is its high amide-selectivity via two processes: i) chemoselective hydrosilylation of amide carbonyls with Vaska’s complex [IrCl(CO)(PPh3)2] and (Me2HSi)2O, and ii) subsequent addition of a variety of mild nucleophiles to the resulting electrophilic iminium ions by the assistance of an acid. The reaction takes place in the presence of a variety of functional groups such as ester and nitro groups.

本文言語English
ページ(範囲)1138-1141
ページ数4
ジャーナルChemistry Letters
48
9
DOI
出版ステータスPublished - 2019

ASJC Scopus subject areas

  • Chemistry(all)

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