Is central dogma a global property of cellular information flow?

Vincent Piras, Masaru Tomita, Kumar Selvarajoo

研究成果: Article査読

11 被引用数 (Scopus)

抄録

The central dogma of molecular biology has come under scrutiny in recent years. Here, we reviewed high-throughput mRNA and protein expression data of Escherichia coli, Saccharomyces cerevisiae, and several mammalian cells. At both single cell and population scales, the statistical comparisons between the entire transcriptomes and proteomes show clear correlation structures. In contrast, the pair-wise correlations of single transcripts to proteins show nullity. These data suggest that the organizing structure guiding cellular processes is observed at omics-wide scale, and not at single molecule level. The central dogma, thus, globally emerges as an average integrated flow of cellular information.

本文言語English
論文番号Article 439
ジャーナルFrontiers in Physiology
3 NOV
DOI
出版ステータスPublished - 2012

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

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