Is SS-A/Ro52 a hydrogen peroxide-sensitive signaling molecule?

Yumiko Nobuhara, Seiji Kawano, Goichi Kageyama, Daisuke Sugiyama, Jun Saegusa, Shunichi Kumagai

研究成果: Short survey査読

12 被引用数 (Scopus)

抄録

SS-A/Ro52 (Ro52) protein is one of the targets of autoantibodies in Sjogren's syndrome and systemic lupus erythematosus. Ro52 structurally belongs to the RING-B-box/coiled-coil family, which appears to carry out diverse functions, but the physiological function of Ro52 remains largely unknown. Here, the authors demonstrate that hydrogen peroxide but not other oxidative stressors induced translocation of Ro52 protein from the cytoplasm to the nucleus and this phenomenon was attenuated by inhibition of MAP kinases, ERK in particular. These findings raise the possibility that SS-A/Ro52 may function as a hydrogen peroxide-selective, oxidative stress-sensitive signaling molecule that is activated via the MAP kinase pathway.

本文言語English
ページ(範囲)385-391
ページ数7
ジャーナルAntioxidants and Redox Signaling
9
3
DOI
出版ステータスPublished - 2007 3
外部発表はい

ASJC Scopus subject areas

  • 生化学
  • 生理学
  • 分子生物学
  • 臨床生化学
  • 細胞生物学

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