Isolation and expression patterns of genes for three angiopoietin-like proteins, Angptl1, 2 and 6 in zebrafish

Yoshiaki Kubota, Yuichi Oike, Shinya Satoh, Yoko Tabata, Yuichi Niikura, Tohru Morisada, Masaki Akao, Takashi Urano, Yasuhiro Ito, Takeshi Miyamoto, Sumiko Watanabe, Toshio Suda

研究成果: Article査読

25 被引用数 (Scopus)

抄録

Angiopoietin-like proteins (Angptls) are known to possess biological activities not only in the vascular system, but in the other mammalian tissues; however, their expression patterns and function in embryogenesis have not been extensively characterized. Here, we identify three zebrafish genes (Zangptl1, Zangptl2 and Zangptl6) highly homologous to mammalian Angptl1/ARP1, Angptl2/ARP2 and Angptl6/AGF, and describe their adult and embryonic temporal and spatial expression patterns. Zangptl1 is expressed faintly in the somites, while Zangptl2 is first detected in the yolk sac extension, spinal cord and branchial arches and is later expressed in the liver primordium and pectoral fin buds. Zangptl6 is expressed in the notochord. In addition to its embryonic expression, Zangptl2 is induced in adult fish during fin regeneration.

本文言語English
ページ(範囲)679-685
ページ数7
ジャーナルGene Expression Patterns
5
5
DOI
出版ステータスPublished - 2005 6

ASJC Scopus subject areas

  • 分子生物学
  • 遺伝学
  • 発生生物学

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