Isolation and structure determination of inostamycin, a novel inhibitor of phosphatidylinositol turnover

Masaya Imoto, Kazuo Umezawa, Yoshikazu Takahashi, Hiroshi Naganawa, Hikaru Nakamura, Yumi Koizumi, Yumi Sasaki, Masa Hamada, Tsutomu Sawa, Tomio Takeuchi, Yoichi Iitaka

研究成果: Article査読

40 被引用数 (Scopus)

抄録

In the course of screening for phosphatidylinosicol turnover inhibitors, we found that a culture broth of a Streptomyces strain strongly inhibited the incorporation of inositol into phosphatidylinositol and its phosphates. The active principle was isolated from the broth through EtOAc extraction, cc, centrifugation partition chromatography, and crystallization. Spectroscopic and crystallographic analysis revealed that it has a novel polyether structure, and we named it inostamycin. Inostamycin inhibited phosphatidylinositol turnover with an IC50 of 0.5 μg/ml in cultured A431 cells.

本文言語English
ページ(範囲)825-829
ページ数5
ジャーナルJournal of Natural Products
53
4
DOI
出版ステータスPublished - 1990
外部発表はい

ASJC Scopus subject areas

  • 分析化学
  • 分子医療
  • 薬理学
  • 薬科学
  • 創薬
  • 補完代替医療
  • 有機化学

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