Isolation and Structure Elucidation of Gymnemic Acids, Antisweet Principles of Gymnema sylvestre

Hong Min Liu, Fumiyuki Kiuchi, Yoshisuke Tsuda

研究成果: Article査読

97 被引用数 (Scopus)

抄録

The structure of gymnemagenin (3/?,16/?,21/?,22a,23,28-hexahydroxy-olean-l 2-ene), the sapogenin of the antisweet principles of Gymnema sylvestre, was established by X-ray analysis of the 3/?,23;21/?,22a-di-0~isopropylidene derivative. On the basis of this result, the structure of deacylgymnemic acid was elucidated as the 3-0-/?-glucuronide from the carbon-13 nuclear magnetic resonance spectra. Five antisweet principles, gymnemic acid-IIl, -IV, -V, -VIII, and -IX, were isolated in pure states from the hot water extract of leaves of Gymnema sylvestre. Of these, three (GA-III, -IV, and -V) were known, while two (GA-VIII and -IX) were new compounds. The structures of GA-VIII and -IX were elucidated as 3'-O-/?-D-ara£i7f0-2-hexulopyranosyl gymnemic acid-III and -IV, respectively.

本文言語English
ページ(範囲)1366-1375
ページ数10
ジャーナルChemical and Pharmaceutical Bulletin
40
6
DOI
出版ステータスPublished - 1992 1 1
外部発表はい

ASJC Scopus subject areas

  • 化学 (全般)
  • 創薬

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