Isolation and Structure of Kurahyne B and Total Synthesis of the Kurahynes

Shinichiro Okamoto, Arihiro Iwasaki, Osamu Ohno, Kiyotake Suenaga

研究成果: Article査読

18 被引用数 (Scopus)

抄録

Kurahyne B (2), a new analogue of kurahyne (1), was isolated from the marine cyanobacterium Okeania sp. Its gross structure was elucidated based on spectroscopic analyses, and the absolute configuration was established by total synthesis. Kurahyne B (2) inhibited the growth of both HeLa and HL60 cells, with IC50 values of 8.1 and 9.0 μM, respectively. The growth-inhibitory activity of kurahyne B was the same as kurahyne (1). In parallel, the first total synthesis of kurahyne (1) was also achieved.

本文言語English
ページ(範囲)2719-2725
ページ数7
ジャーナルJournal of Natural Products
78
11
DOI
出版ステータスPublished - 2015 11月 25

ASJC Scopus subject areas

  • 分析化学
  • 分子医療
  • 薬理学
  • 薬科学
  • 創薬
  • 補完代替医療
  • 有機化学

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