TY - JOUR
T1 - Isolation and Structure of Kurahyne B and Total Synthesis of the Kurahynes
AU - Okamoto, Shinichiro
AU - Iwasaki, Arihiro
AU - Ohno, Osamu
AU - Suenaga, Kiyotake
N1 - Publisher Copyright:
© 2015 The American Chemical Society and American Society of Pharmacognosy.
PY - 2015/11/25
Y1 - 2015/11/25
N2 - Kurahyne B (2), a new analogue of kurahyne (1), was isolated from the marine cyanobacterium Okeania sp. Its gross structure was elucidated based on spectroscopic analyses, and the absolute configuration was established by total synthesis. Kurahyne B (2) inhibited the growth of both HeLa and HL60 cells, with IC50 values of 8.1 and 9.0 μM, respectively. The growth-inhibitory activity of kurahyne B was the same as kurahyne (1). In parallel, the first total synthesis of kurahyne (1) was also achieved.
AB - Kurahyne B (2), a new analogue of kurahyne (1), was isolated from the marine cyanobacterium Okeania sp. Its gross structure was elucidated based on spectroscopic analyses, and the absolute configuration was established by total synthesis. Kurahyne B (2) inhibited the growth of both HeLa and HL60 cells, with IC50 values of 8.1 and 9.0 μM, respectively. The growth-inhibitory activity of kurahyne B was the same as kurahyne (1). In parallel, the first total synthesis of kurahyne (1) was also achieved.
UR - http://www.scopus.com/inward/record.url?scp=84948798629&partnerID=8YFLogxK
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U2 - 10.1021/acs.jnatprod.5b00662
DO - 10.1021/acs.jnatprod.5b00662
M3 - Article
C2 - 26539973
AN - SCOPUS:84948798629
VL - 78
SP - 2719
EP - 2725
JO - Journal of Natural Products
JF - Journal of Natural Products
SN - 0163-3864
IS - 11
ER -
