Isolation and structures of biselyngbyasides B, C, and D from the marine cyanobacterium Lyngbya sp., and the biological activities of biselyngbyasides

Maho Morita, Osamu Ohno, Toshiaki Teruya, Takao Yamori, Toshiyasu Inuzuka, Kiyotake Suenaga

研究成果: Article査読

30 被引用数 (Scopus)

抄録

Bioassay-guided fractionation of the marine cyanobacterium Lyngbya sp. led to the isolation of biselyngbyasides B (3), C (4), and D (5), novel analogs of biselyngbyaside (1) and biselyngbyolide A (2). The gross structures of 3-5 were determined by NMR spectral analyses, and their stereochemistries were established based on NOESY spectra and CD data. Biselyngbyasides (1-3) showed growth-inhibitory activity and apoptosis-inducing activity against both HeLa S 3 cells and HL60 cells. The fura-2 method revealed that biselyngbyasides (1-3) increased the cytosolic Ca 2+ concentration in HeLa S 3 cells.

本文言語English
ページ(範囲)5984-5990
ページ数7
ジャーナルTetrahedron
68
30
DOI
出版ステータスPublished - 2012 7 29

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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