Isolation and Total Synthesis of Beru'amide, an Antitrypanosomal Polyketide from a Marine Cyanobacterium Okeania sp.

Raimu Taguchi, Arihiro Iwasaki, Akira Ebihara, Ghulam Jeelani, Tomoyoshi Nozaki, Kiyotake Suenaga

研究成果: Article査読

1 被引用数 (Scopus)

抄録

A 68 μg amount of an acyclic polyketide, named beru'amide, was isolated from a marine cyanobacterium Okeania sp. Beru'amide contains six unique moieties in its relatively small skeleton. By applying several cutting-edge techniques, including DFT-based chemical shift calculations, we achieved the structure determination and the total synthesis of this highly functionalized scarce natural product. Furthermore, beru'amide was shown to have strong antitrypanosomal activity. 2022 American Chemical Society.

本文言語English
ページ(範囲)4710-4714
ページ数5
ジャーナルOrganic Letters
24
25
DOI
出版ステータスPublished - 2022 7月 1

ASJC Scopus subject areas

  • 生化学
  • 物理化学および理論化学
  • 有機化学

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