Isolation and Total Synthesis of Kinenzoline, an Antitrypanosomal Linear Depsipeptide Isolated from a Marine Salileptolyngbya sp. Cyanobacterium

Naoaki Kurisawa, Keisuke Otomo, Arihiro Iwasaki, Ghulam Jeelani, Tomoyoshi Nozaki, Kiyotake Suenaga

研究成果: Article査読

抄録

Kinenzoline (1), a new linear depsipeptide, was isolated from a marine Salileptolyngbya sp. cyanobacterium. Its structure was elucidated by spectroscopic analyses and degradation reactions. In addition, we achieved a total synthesis of 1 and confirmed its structure. Kinenzoline (1) showed highly selective antiproliferative activity against the causative organism of sleeping sickness, Trypanosoma brucei rhodesiense (IC50 4.5 μM), compared to normal human cells (WI-38, IC50 > 100 μM). Kinenzoline (1) is a promising lead compound for the development of new antitrypanosomal drugs.

本文言語English
ページ(範囲)12528-12536
ページ数9
ジャーナルJournal of Organic Chemistry
86
18
DOI
出版ステータスPublished - 2021 9月 17

ASJC Scopus subject areas

  • 有機化学

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