TY - JOUR
T1 - Isolation of a Drosophila Gene Encoding a Head‐Specific Guanylyl Cyclase
AU - Yoshikawa, Shingo
AU - Miyamoto, Issei
AU - Aruga, Jun
AU - Furuichi, Teiichi
AU - Okano, Hideyuki
AU - Mikoshiba, Katsuhiko
PY - 1993/4
Y1 - 1993/4
N2 - Abstract: We have isolated and characterized a new guanylyl cyclase gene (dgcl) in Drosophila. The deduced amino acid sequence (683 amino acids) most closely resembled the mammalian solubletype guanylyl cyclase α subunit. The cyclase catalytic domain was highly conserved between the mammalian and Drosophila guanylyl cyclases. The dgcl mRNA was detected in wild‐type heads but not in bodies, and its level was reduced in the mutant eyes absent (eya), indicating that dgcl is preferentially expressed in the CNS and in the eye. The enriched distribution in the eye suggests that dgcl may have a role in phototransduction.
AB - Abstract: We have isolated and characterized a new guanylyl cyclase gene (dgcl) in Drosophila. The deduced amino acid sequence (683 amino acids) most closely resembled the mammalian solubletype guanylyl cyclase α subunit. The cyclase catalytic domain was highly conserved between the mammalian and Drosophila guanylyl cyclases. The dgcl mRNA was detected in wild‐type heads but not in bodies, and its level was reduced in the mutant eyes absent (eya), indicating that dgcl is preferentially expressed in the CNS and in the eye. The enriched distribution in the eye suggests that dgcl may have a role in phototransduction.
KW - CNS
KW - Drosophila dgcl gene
KW - Guanylyl cyclase
KW - Phototransduction
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U2 - 10.1111/j.1471-4159.1993.tb03324.x
DO - 10.1111/j.1471-4159.1993.tb03324.x
M3 - Article
C2 - 8095978
AN - SCOPUS:0027409931
SN - 0022-3042
VL - 60
SP - 1570
EP - 1573
JO - Journal of Neurochemistry
JF - Journal of Neurochemistry
IS - 4
ER -