Isolation of a Drosophila Gene Encoding a Head‐Specific Guanylyl Cyclase

Shingo Yoshikawa, Issei Miyamoto, Jun Aruga, Teiichi Furuichi, Hideyuki Okano, Katsuhiko Mikoshiba

研究成果: Article査読

19 被引用数 (Scopus)

抄録

Abstract: We have isolated and characterized a new guanylyl cyclase gene (dgcl) in Drosophila. The deduced amino acid sequence (683 amino acids) most closely resembled the mammalian solubletype guanylyl cyclase α subunit. The cyclase catalytic domain was highly conserved between the mammalian and Drosophila guanylyl cyclases. The dgcl mRNA was detected in wild‐type heads but not in bodies, and its level was reduced in the mutant eyes absent (eya), indicating that dgcl is preferentially expressed in the CNS and in the eye. The enriched distribution in the eye suggests that dgcl may have a role in phototransduction.

本文言語English
ページ(範囲)1570-1573
ページ数4
ジャーナルJournal of Neurochemistry
60
4
DOI
出版ステータスPublished - 1993 4
外部発表はい

ASJC Scopus subject areas

  • 生化学
  • 細胞および分子神経科学

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