Isolation of a major metabolite (i-OHAP) of aprindine and its identification as N-[3-(N,N-diethylamino)propyl]-N-phenyl-2-aminoindan-5-ol

Mikiko Shimizu, Kazuhiko Takatori, Masahiro Kajiwara, Hiroyasu Ogata

研究成果: Article査読

6 被引用数 (Scopus)

抄録

i-OHAP, a major metabolite of aprindine (AP), was isolated by TLC from rat feces and identified as N-13-(N,N-diethylamino)propyl]-N-phenyl-2- aminoindan-5-ol, based on 1H-NMR, the H-H correlation spectroscopy (COSY) spectrum, MS and LC-MS. Its structure was also confirmed by comparison with the synthesized compound. The hydroxy group of i-OHAP was located at the 5- position of the indan ring. AP is a prochiral compound, and the metabolism of AP to i-OHAP was stereoselective. The ratio of (+)/(-)-i-OHAP in rat feces and in human urine was about 5 and 15, respectively.

本文言語English
ページ(範囲)530-534
ページ数5
ジャーナルBiological and Pharmaceutical Bulletin
21
5
DOI
出版ステータスPublished - 1998

ASJC Scopus subject areas

  • 薬理学
  • 薬科学

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「Isolation of a major metabolite (i-OHAP) of aprindine and its identification as N-[3-(N,N-diethylamino)propyl]-N-phenyl-2-aminoindan-5-ol」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

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