Isolation of a novel paxilline analog pyrapaxilline from fungus that inhibits LPS-induced NO production

Chino Matsui, Yoko Ikeda, Hironobu Iinuma, Nobuaki Kushida, Takao Kunisada, Siro Simizu, Kazuo Umezawa

研究成果: Article査読

8 被引用数 (Scopus)

抄録

We have screened microbial culture filtrates for nitrogen monoxide (NO) production inhibitors using mouse macrophage cell line RAW264.7. As a result, paxilline, 21-isopentenylpaxilline and a novel analog of paxilline have been isolated from the culture filtrate of fungus Eupenicillium shearii. The novel analog possesses an additional dihydropyran ring, and was named as pyrapaxilline. This compound inhibited the NO production with lower toxicity than paxilline.

本文言語English
ページ(範囲)787-790
ページ数4
ジャーナルJournal of Antibiotics
67
11
DOI
出版ステータスPublished - 2014 11 1

ASJC Scopus subject areas

  • 薬理学
  • 創薬

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