Isolation of nabscessin C from nocardia abscessus IFM 10029T and A study on biosynthetic pathway for nabscessins

Shoko Hara, Yasumasa Hara, Midori A. Arai, Yoko Kusuya, Hiroki Takahashi, Takashi Yaguchi, Masami Ishibashi

研究成果: Article査読

3 被引用数 (Scopus)

抄録

A new aminocyclitol derivative, designated nabscessin C (1), was isolated from Nocardia abscessus IFM 10029T. Nabcessin C is an isomer of nabscessins A (2) and B (3) with different positioning of the acyl group. Absolute configuration of nabscessin A was determined by conversion into the 2-deoxy-scyllo-inosamine pentaacetyl derivative (4) by hydrolysis and acetylation of 2. The biosynthetic pathway of nabscessins is proposed based on gene expression analysis.

本文言語English
ページ(範囲)976-982
ページ数7
ジャーナルChemical and Pharmaceutical Bulletin
66
10
DOI
出版ステータスPublished - 2018
外部発表はい

ASJC Scopus subject areas

  • Chemistry(all)
  • Drug Discovery

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